Article
Regulation of growth in a neoplastic B cell line by transfected subunits of 3',5'-cyclic adenosine monophosphate-dependent protein kinase.
Endocrinology - 1 Nov 1994
Taskén K, Andersson K B, Erikstein B K, Hansson V, Jahnsen T, Blomhoff H K
Abstract excerpt
cAMP inhibits the proliferation of both normal peripheral blood B and T lymphocytes as well as the proliferation of a human neoplastic B precursor cell line (Reh). To positively show that this is mediated via the the catalytic subunit, C alpha, of cAMP-dependent protein kinase, stably transfected...
Topics
- B-Lymphocytes
- Blotting, Northern
- Cell Division
- Colforsin
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- DNA, Neoplasm
- Humans
- Mutation
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- RNA, Neoplasm
- Thymidine
- Transfection
- Tumor Cells, Cultured
- Zinc