Article
Protein kinase A-dependent inhibition of alkaline phosphatase release by SaOS-2 human osteoblastic cells: studies in new mutant cell lines that express a cyclic AMP-resistant phenotype.
Cell regulation - 1 Nov 1991
Fukayama S, Kearns A K, Skurat R M, Tashjian A H, Bringhurst F R
Abstract excerpt
We have established mutant SaOS-2 cell lines that express a cyclic AMP (cAMP)-resistant phenotype to investigate the regulation and functional importance of orthophosphoric-monoester phosphohydrolase alkaline optimum (ALPase) in the action of parathyroid hormone (PTH). Cells were stably transfected with a plasmid that directs the synthesis of a mutant form of the type I regulatory subunit of protein kinase A...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.