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Article

Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype.

The Journal of biological chemistry - 24 Sept 2004

Yamaguchi Tamio, Wallace Darren P, Magenheimer Brenda S, Hempson Scott J, Grantham Jared J, Calvet James P

Abstract excerpt

cAMP can be either mitogenic or anti-mitogenic, depending on the cell type. We demonstrated previously that cAMP inhibited the proliferation of normal renal epithelial cells and stimulated the proliferation of cells derived from the cysts of polycystic kidney disease (PKD) patients. The protein products of the genes causing PKD, polycystin-1 and polycystin-2, are thought to regulate intracellular calcium levels,...

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PMID: 15263001
DOI: 10.1074/jbc.M405079200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype.PMID 15263001Read ↗

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Activation of Calcium-Sensing Receptor increases intracellular calcium and decreases cAMP and mTOR in PKD1 deficient cells.Semantic proximity Read ↗

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Strategies to inhibit cyst formation in ADPKD.Semantic proximity Read ↗

Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signalingSemantic proximity Read ↗

Deficiency of polycystic kidney disease-1 gene (PKD1) expression increases A(3) adenosine receptors in human renal cells: implications for cAMP-dependent signalling and proliferation of PKD1-mutated cystic cells.Semantic proximity Read ↗

Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formationSemantic proximity Read ↗

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