Article
Expression of human recombinant cAMP phosphodiesterase isozyme IV reverses growth arrest phenotypes in phosphodiesterase-deficient yeast.
Molecular pharmacology - 1 Feb 1991
McHale M M, Cieslinski L B, Eng W K, Johnson R K, Torphy T J, Livi G P
Abstract excerpt
The low-Km cAMP-specific phosphodiesterases (PDEases) are of great pharmacological significance because of their involvement in regulating cAMP concentrations, which, in turn, are responsible for mediating the cellular response to extracellular signals such as hormones and neurotransmitters. We recently reported the isolation of a cDNA clone that encodes a human monocyte low-Km, rolipram-sensitive, cAMP PDEase...
Topics
- 3',5'-Cyclic-AMP Phosphodiesterases
- Cell Division
- Cyclic AMP
- Endopeptidases
- Gene Expression
- Hot Temperature
- Humans
- Isoenzymes
- Molecular Weight
- Mutation
- Phenotype