Article
Zinc inhibition of cAMP signaling.
The Journal of biological chemistry - 5 Apr 2002
Klein Claudette, Sunahara Roger K, Hudson Tracie Y, Heyduk Tomasz, Howlett Allyn C
Abstract excerpt
Zn(2+) is required as either a catalytic or structural component for a large number of enzymes and thus contributes to a variety of important biological processes. We report here that low micromolar concentrations of Zn(2+) inhibited hormone- or forskolin-stimulated cAMP production in N18TG2 neuroblastoma cells. Similarly, low concentrations inhibited hormone- and forskolin-stimulated adenylyl cyclase (AC)...
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