Article
Molecular basis for the 3',5'-cyclic adenosine monophosphate resistance of Kin mutant Y1 adrenocortical tumor cells.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 1993
Olson M F, Krolczyk A J, Gorman K B, Steinberg R A, Schimmer B P
Abstract excerpt
A series of mutant cell lines (Kin) were previously isolated from Y1 adrenocortical tumor cells based on their ability to resist the growth-inhibitory effects of 8-bromo cAMP. In these Kin clones, cAMP-dependent protein kinase (cAMPdPK) was resistant to activation by cAMP as the consequence of mu...
Topics
- 8-Bromo Cyclic Adenosine Monophosphate
- Adenylyl Cyclases
- Adrenal Cortex Neoplasms
- Animals
- Base Sequence
- Blotting, Northern
- Cell Division
- Cyclic AMP
- DNA
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Protein Kinases
- Sulfates
- Tumor Cells, Cultured
- Zinc