Article
The causal relationship between mutations in cAMP-dependent protein kinase and the loss of adrenocorticotropin-regulated adrenocortical functions.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 1992
Wong M, Krolczyk A J, Schimmer B P
Abstract excerpt
The Y1 adrenocortical tumor cell mutants, Kin-7 and Kin-8, harbor point mutations in the regulatory subunit (RI) of the type 1 cAMP-dependent protein kinase (cAMPdPK) that render the enzyme resistant to activation by cAMP. These mutants also are resistant to many of the regulatory effects of ACTH and cAMP. In order to examine the causal relationships between the mutations in cAMPdPK and the resistance to ACTH and...
Topics
- Adenylyl Cyclases
- Adrenal Cortex
- Adrenal Cortex Neoplasms
- Adrenocorticotropic Hormone
- Animals
- Cell Line
- Clone Cells
- Cyclic AMP
- Drug Resistance, Microbial
- Enzyme Activation
- Kinetics