Article
Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jul 1994
Tortora G, Budillon A, Yokozaki H, Clair T, Pepe S, Merlo G, Rohlff C, Cho-Chung Y S
Abstract excerpt
We have recently shown, using antisense strategy, that the RII beta regulatory subunit of cAMP-dependent protein kinase is essential for cAMP-induced growth inhibition and differentiation of HL-60 human leukemia cells. We constructed a retroviral vector for RII beta (MT-RII beta) by inserting human RII beta complementary DNA into the OT1521 retroviral vector plasmid that contains an internal mouse...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.