Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts.

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Article

Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jul 1994

Tortora G, Budillon A, Yokozaki H, Clair T, Pepe S, Merlo G, Rohlff C, Cho-Chung Y S

Abstract excerpt

We have recently shown, using antisense strategy, that the RII beta regulatory subunit of cAMP-dependent protein kinase is essential for cAMP-induced growth inhibition and differentiation of HL-60 human leukemia cells. We constructed a retroviral vector for RII beta (MT-RII beta) by inserting hum...

Topics

3T3 Cells
8-Bromo Cyclic Adenosine Monophosphate
Allosteric Site
Animals
Cadmium
Cell Differentiation
Cell Division
Cyclic AMP
Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit
Cyclic AMP-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

Genetic Vectors

Humans

Isoenzymes

Leukemia, Promyelocytic, Acute

Metallothionein

Mice

Phenotype

Source

Open in PubMed

Identifiers

PMID: 7947390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7947390-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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