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Article

APOBEC3G/F as one possible driving force for co-receptor switch of the human immunodeficiency virus-1.

Medical microbiology and immunology - 1 Feb 2012

Heger Eva, Thielen Alexander, Gilles Ramona, Obermeier Martin, Lengauer Thomas, Kaiser Rolf, Trapp Susanna

Abstract excerpt

Human immunodeficiency virus-1 tropism highly correlates with the amino acid (aa) composition of the third hypervariable region (V3) of gp120. A shift towards more positively charged aa is seen when binding to CXCR4 compared with CCR5 (X4 vs. R5 strains), especially positions 11 and 25 (11/25-rule) predicting X4 viruses in the presence of positively charged residues. At nucleotide levels, negatively or uncharged...

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Source

Identifiers

PMID: 21573951
DOI: 10.1007/s00430-011-0199-9

Genes

CCR5
CGN
CXCR4
GAN
GGN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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