Article
Intrapatient alterations in the human immunodeficiency virus type 1 gp120 V1V2 and V3 regions differentially modulate coreceptor usage, virus inhibition by CC/CXC chemokines, soluble CD4, and the b12 and 2G12 monoclonal antibodies.
Journal of virology - 1 Jan 2004
Nabatov Alexey A, Pollakis Georgios, Linnemann Thomas, Kliphius Aletta, Chalaby Moustapha I M, Paxton William A
Abstract excerpt
We studied human immunodeficiency virus type 1 (HIV-1) chimeric viruses altering in their gp120 V1V2 and V3 envelope regions to better map which genetic alterations are associated with specific virus phenotypes associated with HIV-1 disease progression. The V1V2 and V3 regions studied were based on viruses isolated from an individual with progressing HIV-1 disease. Higher V3 charges were linked with CXCR4 usage,...
Topics
- Antibodies, Monoclonal
- CD4 Antigens
- Chemokine CCL5
- Chemokine CXCL12
- Chemokines, CC
- Chemokines, CXC
- Disease Progression
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Mutation
- Neutralization Tests