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Article

Substitution of gp120 C4 region compensates for V3 loss-of-fitness mutations in HIV-1 CRF01_AE co-receptor switching.

Emerging microbes & infections - 1 Dec 2023

Yu Yueyang, Feng Yi, Zhou Zehua, Li Kang, Hu Xiaoyan, Liao Lingjie, Xing Hui, Shao Yimig

Abstract excerpt

HIV-1 infection is mediated by a viral envelope subsequently binding to CD4 receptor and two main coreceptors, CCR5 (R5) for primary infection and CXCR4 (X4) in chronic infection. Switching from R5 to X4 tropism in HIV-1 infection is associated with increased viral pathogenesis and disease progression. The coreceptor switching is mainly due to variations in the V3 loop, while the mechanism needs to be further...

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Identifiers

PMID: 36647730
DOI: 10.1080/22221751.2023.2169196
PMCID: PMC9980400

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