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Article

Mutations affecting cleavage at the p10-capsid protease cleavage site block Rous sarcoma virus replication.

Retrovirology - 27 Sept 2005

Vana Marcy L, Chen Aiping, Boross Peter, Weber Irene, Colman Dalbinder, Barklis Eric, Leis Jonathan

Abstract excerpt

A series of amino acid substitutions (M239F, M239G, P240F, V241G) were placed in the p10-CA protease cleavage site (VVAM*PVVI) to change the rate of cleavage of the junction. The effects of these substitutions on p10-CA cleavage by RSV PR were confirmed by measuring the kinetics of cleavage of model peptide substrates containing the wild type and mutant p10-CA sites. The effects of these substitutions on...

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Identifiers

PMID: 16188035
DOI: 10.1186/1742-4690-2-58
PMCID: PMC1262776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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