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Article

Separate functional domains of the herpes simplex virus type 1 protease: evidence for cleavage inside capsids.

Journal of virology - 1 Jul 1996

Robertson B J, McCann P J, Matusick-Kumar L, Newcomb W W, Brown J C, Colonno R J, Gao M

Abstract excerpt

The herpes simplex virus type 1 (HSV-1) protease (Pra) and related proteins are involved in the assembly of viral capsids and virion maturation. Pra is a serine protease, and the active-site residue has been mapped to amino acid (aa) 129 (Ser). This 635-aa protease, encoded by the UL26 gene, is autoproteolytically processed at two sites, the release (R) site between amino acid residues 247 and 248 and the...

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Identifiers

PMID: 8676454
DOI: 10.1128/JVI.70.7.4317-4328.1996
PMCID: PMC190364

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