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Article

Thymidylate synthase germline polymorphisms in rectal cancer patients treated with neoadjuvant chemoradiotherapy based on 5-fluorouracil.

Journal of cancer research and clinical oncology - 1 Nov 2010

Páez David, Paré Laia, Altés Albert, Sancho-Poch Francesc Josep, Petriz Lourdes, Garriga Jordi, Monill Josep Maria, Salazar Juliana, del Rio Elisabeth, Barnadas Agustí, Marcuello Eugenio, Baiget Montserrat

Abstract excerpt

PURPOSE: Chemoradiotherapy using 5-fluorouracil has shown to be effective treatment for rectal cancer. Thymidylate synthase (TS) is an important target enzyme for the fluoropyrimidines. However, the predictive role of TS levels in early stage rectal cancer is not yet well understood. We analyzed...

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Identifiers

PMID: 20165956
DOI: 10.1007/s00432-010-0826-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20165956-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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