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Article

Pharmacogenetic analysis in neoadjuvant chemoradiation for rectal cancer: high incidence of somatic mutations and their relation with response.

Pharmacogenomics - 1 Jun 2010

Balboa Emilia, Duran Goretti, Lamas Maria Jesus, Gomez-Caamaño Antonio, Celeiro-Muñoz Catuxa, Lopez Rafael, Carracedo Angel, Barros Francisco

Abstract excerpt

AIMS: The identification of predictive markers of response to chemoradiotherapy treatment remains a promising approach for patient management in order to obtain the best response with minor side effects. Initially, we investigated whether the analysis of several markers previously studied and others not yet evaluated could predict response to 5-fluorouracil- and capecitabine-based neoadjuvant treatment in locally...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20504250
DOI: 10.2217/pgs.10.51

Genes

XRCC1
EGFR
ERCC1
ERCC2
MTHFR
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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