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Article

Detecting copy number status and uncovering subclonal markers in heterogeneous tumor biopsies.

BMC genomics - 11 May 2011

Parisi Fabio, Ariyan Stephan, Narayan Deepak, Bacchiocchi Antonella, Hoyt Kathleen, Cheng Elaine, Xu Fang, Li Peining, Halaban Ruth, Kluger Yuval

Abstract excerpt

BACKGROUND: Genomic aberrations can be used to determine cancer diagnosis and prognosis. Clinically relevant novel aberrations can be discovered using high-throughput assays such as Single Nucleotide Polymorphism (SNP) arrays and next-generation sequencing, which typically provide aggregate signals of many cells at once. However, heterogeneity of tumor subclones dramatically complicates the task of detecting...

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PMID: 21569352
DOI: 10.1186/1471-2164-12-230
PMCID: PMC3114747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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