Article

MAGOS: Discovering Subclones in Tumors Sequenced at Standard Depths

2019-10-02

Abstract excerpt

<h4>ABSTRACT</h4> Understanding intratumor heterogeneity is critical to designing personalized treatments and improving clinical outcomes of cancers. Such investigations require accurate delineation of the subclonal composition of a tumor, which to date can only be reliably inferred from deep-sequencing data (>300x depth). To enable accurate subclonal discovery in tumors sequenced at standard depths (30-50x), we...

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Literature Corpus work: baa048d5-664c-598b-bc60-b2401e394178
DOI: 10.1101/790386

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