Article
Identification of Genomic Aberrations in Cancer Subclones from Heterogeneous Tumor Samples.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Xia Hong, Liu Yuanning, Wang Minghui, Li Ao
Abstract excerpt
Tumor samples are usually heterogeneous, containing admixture of more than one kind of tumor subclones. Studies of genomic aberrations from heterogeneous tumor data are hindered by the mixed signal of tumor subclone cells. Most of the existing algorithms cannot distinguish contributions of different subclones from the measured single nucleotide polymorphism (SNP) array signals, which may cause erroneous...
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