Article

Resolving sub-clonal heterogeneity within cell-line growths by single cell sequencing genomic DNA

2019-09-05

Abstract excerpt

<h4>ABSTRACT</h4> We performed shallow single-cell sequencing of genomic DNA across 1,475 cells from a well-studied cell-line, COLO829, to resolve overall tumor complexity and clonality. This melanoma tumor-line has been previously characterized by multiple technologies and provides a benchmark for evaluating somatic alterations, though has exhibited conflicting and indeterminate copy number states. We identified...

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Literature Corpus work: 2bcca27b-d3ab-5295-b010-65eb60269d26
DOI: 10.1101/757211

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