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Article

Eukaryotic initiation factor 2alpha phosphorylation is required for B-cell maturation and function in mice.

Haematologica - 1 Sept 2011

Mielke Nina, Schwarzer Rolf, Calkhoven Cornelis F, Kaufman Randal J, Dörken Bernd, Leutz Achim, Jundt Franziska

Abstract excerpt

BACKGROUND: The control of translation initiation is a crucial component in the regulation of gene expression. The eukaryotic initiation factor 2α (eIF2α) mediates binding of the initiator transfer-messenger-RNA to the AUG initiation codon, and thus controls a rate-limiting step in translation initiation. Phosphorylation of eIF2α at serine 51 is linked to cellular stress response and attenuates translation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21565905
DOI: 10.3324/haematol.2011.042853
PMCID: PMC3166095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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