Developmental Stage-Specific Changes in Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells and Erythroid Progenitors to Impaired Ribosome Biogenesis.

Abstract excerpt

Adult hematopoietic stem cell (HSC) self-renewal requires precise control of protein synthesis, but fetal and adult HSCs have distinct self-renewal mechanisms and lineage outputs. This raises the question of whether protein synthesis rates change with age. Here, we show that protein synthesis rates decline during HSC ontogeny, yet erythroid protein synthesis rates increase. A ribosomal mutation that impairs...

Topics

• Animals
• Bone Marrow Cells
• Cell Differentiation
• Erythrocytes
• Erythropoiesis
• Fetal Development
• Fetus
• Hematopoietic Stem Cell Transplantation
• Hematopoietic Stem Cells
• Liver
• Mice