Article
4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy.
American journal of respiratory cell and molecular biology - 1 Aug 2005
Zhou Limei, Goldsmith Adam M, Bentley J Kelley, Jia Yue, Rodriguez Michael L, Abe Mark K, Fingar Diane C, Hershenson Marc B
Abstract excerpt
The molecular mechanisms of airway smooth muscle hypertrophy, a feature of severe asthma, are poorly understood. We previously established a conditionally immortalized human bronchial smooth muscle cell line with a temperature-sensitive SV40 large T antigen. Temperature shift and loss of large T cause G1-phase cell cycle arrest that is accompanied by increased airway smooth muscle cell size. In the present study,...
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