The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.

doi:10.1038/sj.emboj.7601166

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Article

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.

The EMBO journal - 21 Jun 2006

Shahbazian David, Roux Philippe P, Mieulet Virginie, Cohen Michael S, Raught Brian, Taunton Jack, Hershey John W B, Blenis John, Pende Mario, Sonenberg Nahum

Abstract excerpt

The eukaryotic translation initiation factor 4B (eIF4B) plays a critical role in recruiting the 40S ribosomal subunit to the mRNA. In response to insulin, eIF4B is phosphorylated on Ser422 by S6K in a rapamycin-sensitive manner. Here we demonstrate that the p90 ribosomal protein S6 kinase (RSK) phosphorylates eIF4B on the same residue. The relative contribution of the RSK and S6K modules to the phosphorylation of...

Topics

3-Phosphoinositide-Dependent Protein Kinases
Amino Acid Sequence
Animals
Catalysis
Eukaryotic Initiation Factor-3
Eukaryotic Initiation Factors
Extracellular Signal-Regulated MAP Kinases
HeLa Cells
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MAP Kinase Signaling System

Male

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Mutation

Phosphatidylinositol 3-Kinases

Phosphorylation

Phosphoserine

Source

Open in PubMed Open full text

Identifiers

PMID: 16763566
DOI: 10.1038/sj.emboj.7601166
PMCID: PMC1500846

Genes

PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity.PMID 16763566Read ↗

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.Semantic proximity Read ↗

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases.Semantic proximity Read ↗

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.Semantic proximity Read ↗

The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k.Semantic proximity Read ↗

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway.Semantic proximity Read ↗

A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.Semantic proximity Read ↗

Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a).Semantic proximity Read ↗

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PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex.Semantic proximity Read ↗

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.Semantic proximity Read ↗

Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 bindingSemantic proximity Read ↗

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