Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation.

Journal of thrombosis and haemostasis : JTH - 1 Nov 2015

Ricciardi S, Miluzio A, Brina D, Clarke K, Bonomo M, Aiolfi R, Guidotti L G, Falciani F, Biffo S

Abstract excerpt

BACKGROUND: Ribosomopathies constitute a class of inherited disorders characterized by defects in ribosome biogenesis and function. Classically, bone marrow (BM) failure is a clinical symptom shared between these syndromes, including Shwachman-Bodian-Diamond syndrome (SBDS). Eukaryotic translation initiation factor 6 (eIF6) is a critical translation factor that rescues the quasilethal effect of the loss of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Diseases
Share to Electron Transport Complex I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exocrine Pancreatic Insufficiency

Share to G1 Phase

Share to Lipomatosis

Share to Megakaryocytes

Share to Peptide Initiation Factors

Share to Thrombopoiesis

Source

Identifiers

PMID: 26391622
DOI: 10.1111/jth.13150

Genes

SBDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation.PMID 26391622Read ↗

Functional impact of the eIF6 N106S mutation on ribosome biogenesis in wild type and Shwachman-Diamond syndrome cells.Semantic proximity Read ↗

Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway.Semantic proximity Read ↗

G6b-B regulates an essential step in megakaryocyte maturationSemantic proximity Read ↗

The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet productionSemantic proximity Read ↗

Haploinsufficiency of the essential gene RpS12 causes defects in erythropoiesis and hematopoietic stem cell maintenanceSemantic proximity Read ↗

Developmental stage-specific changes in protein synthesis differentially sensitize hematopoietic stem cells and erythroid progenitors to impaired ribosome biogenesisSemantic proximity Read ↗

G6b-B regulates an essential step in megakaryocyte maturationSemantic proximity Read ↗

Impaired ribosomal subunit association in Shwachman-Diamond syndromeSemantic proximity Read ↗

Maturation stage–specific regulation of megakaryopoiesis by pointed-domain Ets proteinsSemantic proximity Read ↗

EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndromeSemantic proximity Read ↗

Altered translation of GATA1 in Diamond-Blackfan anemia.Semantic proximity Read ↗

Neonatal expression of RNA-binding protein IGF2BP3 regulates the human fetal-adult megakaryocyte transitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.