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Article

Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis.

Genes & development - 15 Dec 2015

Kadri Zahra, Lefevre Carine, Goupille Olivier, Penglong Tipparat, Granger-Locatelli Marine, Fucharoen Suthat, Maouche-Chretien Leila, Leboulch Philippe, Chretien Stany

Abstract excerpt

Tight coordination of cell proliferation and differentiation is central to red blood cell formation. Erythropoietin controls the proliferation and survival of red blood cell precursors, while variations in GATA-1/FOG-1 complex composition and concentrations drive their maturation. However, clear evidence of cross-talk between molecular pathways is lacking. Here, we show that erythropoietin activates AKT, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26680303
DOI: 10.1101/gad.267633.115
PMCID: PMC4699388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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