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Article

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells.

Cancer cell - 1 Jun 2004

Avdulov Svetlana, Li Shunan, Michalek Van, Burrichter David, Peterson Mark, Perlman David M, Manivel J Carlos, Sonenberg Nahum, Yee Douglas, Bitterman Peter B, Polunovsky Vitaly A

Abstract excerpt

Common human malignancies acquire derangements of the translation initiation complex, eIF4F, but their functional significance is unknown. Hypophosphorylated 4E-BP proteins negatively regulate eIF4F assembly by sequestering its mRNA cap binding component eIF4E, whereas hyperphosphorylation abrogates this function. We found that breast carcinoma cells harbor increases in the eIF4F constituent eIF4GI and...

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PMID: 15193258
DOI: 10.1016/j.ccr.2004.05.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells.PMID 15193258Read ↗

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