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Article

Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth.

Molecular and cellular biology - 1 Mar 2002

Lachance Pascal E D, Miron Mathieu, Raught Brian, Sonenberg Nahum, Lasko Paul

Abstract excerpt

Eukaryotic translation initiation factor 4E (eIF4E) binds to the cap structure at the 5' end of mRNAs and is a critical target for the control of protein synthesis. eIF4E is phosphorylated in many systems in response to extracellular stimuli, but biochemical evidence to date has been equivocal as to the biological significance of this modification. Here we use a genetic approach to this problem. We show that, in...

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Identifiers

PMID: 11865045
DOI: 10.1128/MCB.22.6.1656-1663.2002
PMCID: PMC135594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth.PMID 11865045Read ↗

Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo.Semantic proximity Read ↗

The translation initiation factor homolog eif4e1c regulates cardiomyocyte metabolism and proliferation during heart regenerationSemantic proximity Read ↗

Functional analysis of seven genes encoding eight translation initiation factor 4E (eIF4E) isoforms in Drosophila.Semantic proximity Read ↗

4E-BP functions as a metabolic brake used under stress conditions but not during normal growth.Semantic proximity Read ↗

The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation.Semantic proximity Read ↗

Drosophila Lk6 kinase controls phosphorylation of eukaryotic translation initiation factor 4E and promotes normal growth and development.Semantic proximity Read ↗

Translation of a small subset of Caenorhabditis elegans mRNAs is dependent on a specific eukaryotic translation initiation factor 4E isoform.Semantic proximity Read ↗

Mutants of eukaryotic initiation factor eIF-4E with altered mRNA cap binding specificity reprogram mRNA selection by ribosomes in Saccharomyces cerevisiae.Semantic proximity Read ↗

The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

A cyclin-dependent kinase, CDK11/p58, represses cap-dependent translation during mitosisSemantic proximity Read ↗

Repressor binding to a dorsal regulatory site traps human eIF4E in a high cap-affinity state.Semantic proximity Read ↗

Diminution of eIF4E activity suppresses parkin mutant phenotypes.Semantic proximity Read ↗

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