Interference with the assembly of a virus-host transcription complex by peptide competition.

doi:10.1038/344257a0

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Article

Interference with the assembly of a virus-host transcription complex by peptide competition.

Nature - 15 Mar 1990

Haigh A, Greaves R, O'Hare P

Abstract excerpt

Induction of transcription of the immediate-early (IE) genes of herpes simplex virus (HSV) involves the assembly of a DNA-binding complex containing the cellular transcription factor Oct-1 and the virus regulatory protein Vmw65 (VP16). Complex assembly can be observed using deletion variants of V...

Topics

Amino Acid Sequence
Base Sequence
Binding Sites
DNA
DNA-Binding Proteins
HeLa Cells
Host Cell Factor C1
Immediate-Early Proteins
Molecular Sequence Data
Mutation
Octamer Transcription Factor-1
Phosphoproteins
Simplexvirus
Trans-Activators
Transcription Factors
Transcription, Genetic
Transcriptional Activation
Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 2156166
DOI: 10.1038/344257a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2156166-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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