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Article

Interference with the assembly of a virus-host transcription complex by peptide competition.

Nature - 15 Mar 1990

Haigh A, Greaves R, O'Hare P

Abstract excerpt

Induction of transcription of the immediate-early (IE) genes of herpes simplex virus (HSV) involves the assembly of a DNA-binding complex containing the cellular transcription factor Oct-1 and the virus regulatory protein Vmw65 (VP16). Complex assembly can be observed using deletion variants of Vmw65 which lack the acidic C-terminal activation domain and are therefore defective for IE transactivation. Similar...

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Identifiers

PMID: 2156166
DOI: 10.1038/344257a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interference with the assembly of a virus-host transcription complex by peptide competition.PMID 2156166Read ↗

Protein interactions in the herpes simplex virus type 1 VP16-induced complex: VP16 peptide inhibition and mutational analysis of host cell factor requirements.Semantic proximity Read ↗

Amino acid substitutions in the herpes simplex virus transactivator VP16 uncouple direct protein-protein interaction and DNA binding from complex assembly and transactivation.Semantic proximity Read ↗

Structural requirements in the herpes simplex virus type 1 transactivator Vmw65 for interaction with the cellular octamer-binding protein and target TAATGARAT sequences.Semantic proximity Read ↗

Exploitation of the Mediator complex by virusesSemantic proximity Read ↗

The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain.Semantic proximity Read ↗

Defective transcriptional activation by diverse VP16 mutants associated with a common inability to form open promoter complexes.Semantic proximity Read ↗

A herpes simplex virus type 1 mutant containing a nontransinducing Vmw65 protein establishes latent infection in vivo in the absence of viral replication and reactivates efficiently from explanted trigeminal ganglia.Semantic proximity Read ↗

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Separation of sequence requirements for HSV-1 Vmw110 multimerisation and interaction with a 135-kDa cellular protein.Semantic proximity Read ↗

Transcriptional activation by DNA-binding derivatives of HSV-1 VP16 that lack the carboxyl-terminal acidic activation domain.Semantic proximity Read ↗

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