Structure of the VP16 transactivator target in the Mediator.

doi:10.1038/nsmb.1999

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Article

Structure of the VP16 transactivator target in the Mediator.

Nature structural & molecular biology - 1 Apr 2011

Milbradt Alexander G, Kulkarni Madhura, Yi Tingfang, Takeuchi Koh, Sun Zhen-Yu J, Luna Rafael E, Selenko Philipp, Näär Anders M, Wagner Gerhard

Abstract excerpt

The human Mediator coactivator complex interacts with many transcriptional activators and facilitates recruitment of RNA polymerase II to promote target gene transcription. The MED25 subunit is a critical target of the potent herpes simplex 1 viral transcriptional activator VP16. Here we determine the solution structure of the MED25 VP16-binding domain (VBD) and define its binding site for the N-terminal portion...

Topics

Herpes Simplex Virus Protein Vmw65
Humans
Mediator Complex
Mutation
Nuclear Magnetic Resonance, Biomolecular
Point Mutation
Protein Conformation

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Identifiers

PMID: 21378963
DOI: 10.1038/nsmb.1999
PMCID: PMC3076674

Genes

MED25

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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