The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain.

doi:10.1101/gad.5.12b.2555

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Article

The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain.

Genes & development - 1 Dec 1991

Stern S, Herr W

Abstract excerpt

The homeo domain of the Oct-1 transcription factor directs formation of a multiprotein-DNA complex containing Oct-1, the herpes simplex virus (HSV) trans-activator VP16, and a second host cell factor (HCF). This VP16-induced complex alters the regulatory activity of Oct-1, in part, by associating it with the potent VP16 acidic transcriptional activation domain. Here, we show that in the absence of HCF, VP16 can...

Topics

Amino Acid Sequence
Base Sequence
Carrier Proteins
DNA, Viral
DNA-Binding Proteins
Genes, Homeobox
Herpes Simplex Virus Protein Vmw65
Host Cell Factor C1
Integration Host Factors
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Octamer Transcription Factor-1

Simplexvirus

Trans-Activators

Transcription Factors

Transcription, Genetic

Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 1684335
DOI: 10.1101/gad.5.12b.2555

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1684335-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The herpes simplex virus trans-activator VP16 recognizes the Oct-1 homeo domain: evidence for a homeo domain recognition subdomain.PMID 1684335Read ↗

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