Article
Transcriptional activation by DNA-binding derivatives of HSV-1 VP16 that lack the carboxyl-terminal acidic activation domain.
Virology - 10 May 1995
Popova B, Bilan P, Xiao P, Faught M, Capone J P
Abstract excerpt
The herpes simplex virus transactivator VP16 directs the assembly of a multicomponent protein-DNA complex with cellular components Oct-1 and VCAF-1, contributing a potent carboxyl-terminal acidic activation domain that is essential for activation of gene expression in mammalian cells. We show her...
Topics
- Animals
- Base Sequence
- Cell Line
- DNA Probes
- DNA, Fungal
- DNA-Binding Proteins
- Fungal Proteins
- Genes, Reporter
- HeLa Cells
- Herpes Simplex Virus Protein Vmw65
- Host Cell Factor C1
- Humans
- Molecular Sequence Data
- Mutation
- Octamer Transcription Factor-1
- Saccharomyces cerevisiae
- Species Specificity
- Trans-Activators