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Article

Defective transcriptional activation by diverse VP16 mutants associated with a common inability to form open promoter complexes.

The Journal of biological chemistry - 25 Feb 1994

Jiang Y, Triezenberg S J, Gralla J D

Abstract excerpt

Three different types of VP16 mutants were assayed in vitro. These included deletion of the C-terminal activation subdomain and alterations in either the acidic or non-acidic components of the minimal activation domain. The mutant GAL4-VP16 proteins were found to be transcriptionally defective using a HeLa cell nuclear extract. In all three cases the loss of transcription activity was accompanied by a...

Topics

Fungal Proteins
HeLa Cells
Humans
Mutation
Promoter Regions, Genetic
Trans-Activators
Transcriptional Activation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8119881

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8119881-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Defective transcriptional activation by diverse VP16 mutants associated with a common inability to form open promoter complexes.PMID 8119881Read ↗

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