Protein interactions in the herpes simplex virus type 1 VP16-induced complex: VP16 peptide inhibition and mutational analysis of host cell factor requirements.

doi:10.1128/JVI.71.5.3886-3894.1997

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Article

Protein interactions in the herpes simplex virus type 1 VP16-induced complex: VP16 peptide inhibition and mutational analysis of host cell factor requirements.

Journal of virology - 1 May 1997

Simmen K A, Newell A, Robinson M, Mills J S, Canning G, Handa R, Parkes K, Borkakoti N, Jupp R

Abstract excerpt

The herpes simplex virus VP16 protein functions as a potent transcriptional activator and targets DNA sites with the consensus TAATGARAT present in all the viral immediate-early gene promoters. To do so, VP16 directs assembly of a multiprotein complex involving two cellular proteins, host cell fa...

Topics

Amino Acid Sequence
DNA-Binding Proteins
Herpes Simplex Virus Protein Vmw65
Homeodomain Proteins
Host Cell Factor C1
Humans
Molecular Sequence Data
Mutation
Octamer Transcription Factor-1
Proteins
Structure-Activity Relationship
Transcription Factors

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Identifiers

PMID: 9094665
DOI: 10.1128/JVI.71.5.3886-3894.1997
PMCID: PMC191540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9094665-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.