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Exploitation of the Mediator complex by viruses

21 Apr 2022

Abstract excerpt

iruses and the discovery of MediatorJust as biophysicists were identifying the component proteins of functional RNA polymerase II (RNAPII) complexes, virologists were identifying viral proteins that control it with peculiar efficiency [1].Purified transcription components phosphorylate the RNAPII carboxyl-terminal domain (CTD) to initiate transcription, and this is enhanced by viral transactivators.In this way,...

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PMID: 35446926
DOI: 10.1371/journal.ppat.1010422

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