Structural requirements in the herpes simplex virus type 1 transactivator Vmw65 for interaction with the cellular octamer-binding protein and target TAATGARAT sequences.

doi:10.1128/JVI.64.6.2716-2724.1990

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Article

Structural requirements in the herpes simplex virus type 1 transactivator Vmw65 for interaction with the cellular octamer-binding protein and target TAATGARAT sequences.

Journal of virology - 1 Jun 1990

Greaves R F, O'Hare P

Abstract excerpt

Herpes simplex virus type 1 virion protein Vmw65 forms a complex (TRF.C) with TAATGARAT sequences and the cellular transcription factor oct-1, which has been implicated as an intermediate in the activation of gene expression by Vmw65. To examine structural requirements within Vmw65 for this interaction, we analyzed extracts of transfected cells that express mutant Vmw65 proteins by gel retardation assay and...

Topics

Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Cell Line
Chromosome Deletion
DNA-Binding Proteins
Genetic Vectors
HIV-1
Host Cell Factor C1
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Octamer Transcription Factor-1

Oligonucleotide Probes

Plasmids

Restriction Mapping

Trans-Activators

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 2335815
DOI: 10.1128/JVI.64.6.2716-2724.1990
PMCID: PMC249451

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2335815-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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