Article
Amino acid substitutions in the herpes simplex virus transactivator VP16 uncouple direct protein-protein interaction and DNA binding from complex assembly and transactivation.
The Journal of biological chemistry - 1 Dec 1995
Shaw P, Knez J, Capone J P
Abstract excerpt
The herpes simplex virus transactivator VP16 directs the assembly of a multicomponent protein-DNA complex that requires the participation of two cellular factors, the POU homeodomain protein Oct-1, which binds independently to response elements, and VCAF-1 (VP16 complex assembly factor; also call...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA-Binding Proteins
- Herpes Simplex Virus Protein Vmw65
- Homeodomain Proteins
- Host Cell Factor C1
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Octamer Transcription Factor-1
- Oligodeoxyribonucleotides
- Protein Binding
- Transcription Factors
- Transcriptional Activation