Article
A herpes simplex virus type 1 mutant containing a nontransinducing Vmw65 protein establishes latent infection in vivo in the absence of viral replication and reactivates efficiently from explanted trigeminal ganglia.
Journal of virology - 1 Apr 1990
Steiner I, Spivack J G, Deshmane S L, Ace C I, Preston C M, Fraser N W
Abstract excerpt
Vmw65, a herpes simplex virus type 1 (HSV-1) tegument protein, in association with cellular proteins, transactivates viral immediate early genes. In order to examine the role of Vmw65 during acute and latent infection in vivo, a mutant virus (in1814), containing a 12-base-pair insertion in the Vmw65 gene, which lacks the transactivating function of Vmw65 (C. I. Ace, T. A. McKee, J. M. Ryan, J. M. Cameron, and C....
Topics
- Animals
- Base Sequence
- DNA, Viral
- Female
- Herpes Simplex
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Phosphoproteins
- Simplexvirus