Article
BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum.
Gut - 1 Aug 2004
Kambara T, Simms L A, Whitehall V L J, Spring K J, Wynter C V A, Walsh M D, Barker M A, Arnold S, McGivern A, Matsubara N, Tanaka N, Higuchi T, Young J, Jass J R, Leggett B A
Abstract excerpt
BACKGROUND AND AIMS: Mutations in BRAF have been linked with colorectal cancers (CRC) showing high level microsatellite instability (MSI-H). However, the distribution of BRAF mutations in MSI-H cancers remains to be clarified with respect to precursor lesions and the CpG island methylator phenotype (CIMP). METHODS: Forty three hyperplastic polyps (HP), nine mixed polyps (MP), five serrated adenomas (SA), 28...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.