Article
A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma.
Molecular cancer - 8 Jul 2014
Siraj Abdul K, Bu Rong, Prabhakaran Sarita, Bavi Prashant, Beg Shaham, Al Hazmi Mohsen, Al-Rasheed Maha, Alobaisi Khadija, Al-Dayel Fouad, AlManea Hadeel, Al-Sanea Nasser, Uddin Shahab, Al-Kuraya Khawla S
Abstract excerpt
BACKGROUND: Recent studies emphasize the role of BRAF as a genetic marker for prediction, prognosis and risk stratification in colorectal cancer. Earlier studies have reported the incidence of BRAF mutations in the range of 5-20% in colorectal carcinomas (CRC) and are predominantly seen in the serrated adenoma-carcinoma pathway characterized by microsatellite instability (MSI-H) and hypermethylation of the MLH1...
Topics
- Adaptor Proteins, Signal Transducing
- Adenomatous Polyposis Coli
- Aged
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- Female
- Humans
- Male
- Microsatellite Instability