Article
Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Mar 2005
Young Joanne, Barker Melissa A, Simms Lisa A, Walsh Michael D, Biden Kelli G, Buchanan Daniel, Buttenshaw Ron, Whitehall Vicki L J, Arnold Sven, Jackson Leigh, Kambara Takeshi, Spring Kevin J, Jenkins Mark A, Walker Graeme J, Hopper John L, Leggett Barbara A, Jass Jeremy R
Abstract excerpt
BACKGROUND AND AIMS: Recently, an alternative pathway of tumorigenesis has been identified in the colorectum associated with serrated precursor lesions, variable levels of microsatellite instability (MSI-V), and driven in part by activating mutations in the BRAF proto-oncogene (V599E). Somatic BRAF mutations in hereditary nonpolyposis colon cancer (HNPCC) are rarely observed. Here, we discuss their role in the...
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