Article
BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?
BMC cancer - 9 Sept 2008
Velho Sérgia, Moutinho Cátia, Cirnes Luís, Albuquerque Cristina, Hamelin Richard, Schmitt Fernando, Carneiro Fátima, Oliveira Carla, Seruca Raquel
Abstract excerpt
BACKGROUND: BRAF, KRAS and PIK3CA mutations are frequently found in sporadic colorectal cancer (CRC). In contrast to KRAS and PIK3CA mutations, BRAF mutations are associated with tumours harbouring CpG Island methylation phenotype (CIMP), MLH1 methylation and microsatellite instability (MSI). We aimed at determine the frequency of KRAS, BRAF and PIK3CA mutations in the process of colorectal tumourigenesis using a...
Topics
- Carcinoma
- Class I Phosphatidylinositol 3-Kinases
- Colonic Polyps
- Colorectal Neoplasms
- DNA Methylation
- DNA Mutational Analysis
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Humans
- Microsatellite Repeats
- Models, Genetic
- Mutation