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Article

Translation deficiency of the Sabin type 3 poliovirus genome: association with an attenuating mutation C472----U.

Virology - 1 Mar 1990

Svitkin Y V, Cammack N, Minor P D, Almond J W

Abstract excerpt

Previous studies have shown that the genome of Sabin type 3 poliovaccine strain (P3/Leon 12a1b) possesses a diminished translation efficiency as compared to genomes of closely related neurovirulent strains, the neurovirulent progenitor (P3/Leon/37), or a revertant (P3/119/70) of the vaccine (Y.V. Svitkin, S.V. Maslova, and V.I. Agol, 1985, Virology 147, 243-252). Here we attempted to evaluate the contribution of...

Topics

Animals
Cell Line
Cell-Free System
Cloning, Molecular
Genes, Viral
Kinetics
Mutation
Poliovirus
Poliovirus Vaccine, Oral
Protein Biosynthesis
RNA, Messenger
RNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vaccines, Attenuated

Virulence

Source

Identifiers

PMID: 2155504
DOI: 10.1016/0042-6822(90)90190-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2155504-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Translation deficiency of the Sabin type 3 poliovirus genome: association with an attenuating mutation C472----U.PMID 2155504Read ↗

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