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Article

Translation deficiency of the Sabin type 3 poliovirus genome: association with an attenuating mutation C472----U.

Virology - 1 Mar 1990

Svitkin Y V, Cammack N, Minor P D, Almond J W

Abstract excerpt

Previous studies have shown that the genome of Sabin type 3 poliovaccine strain (P3/Leon 12a1b) possesses a diminished translation efficiency as compared to genomes of closely related neurovirulent strains, the neurovirulent progenitor (P3/Leon/37), or a revertant (P3/119/70) of the vaccine (Y.V. Svitkin, S.V. Maslova, and V.I. Agol, 1985, Virology 147, 243-252). Here we attempted to evaluate the contribution of...

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PMID: 2155504
DOI: 10.1016/0042-6822(90)90190-3

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