Article
Mutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infections.
Medical microbiology and immunology - 1 Feb 2015
Timm Joerg, Walker Christopher M
Abstract excerpt
Over the past two decades, much has been learned about how human viruses evade T cell immunity to establish persistent infection. The lessons are particularly relevant to two hepatotropic viruses, HBV and HCV, that are very significant global public health problems. Although HCV and HBV are very different, the natural history of persistent infections with these viruses in humans shares some common features...
Topics
- CD8-Positive T-Lymphocytes
- Epitopes
- Evolution, Molecular
- Hepacivirus
- Hepatitis B
- Hepatitis B virus
- Hepatitis C
- Hepatitis Viruses
- Humans
- Immune Evasion
- Immunotherapy
- Mutation