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Article

Anti-hepatitis C virus T-cell immunity in the context of multiple exposures to the virus.

PloS one - 1 Jan 2015

Pfafferott Katja, Deshpande Pooja, McKinnon Elizabeth, Merani Shahzma, Lucas Andrew, Heckerman David, Mallal Simon, John Mina, Gaudieri Silvana, Lucas Michaela

Abstract excerpt

Characterisation of Hepatitis C virus (HCV)-specific CD8+ T-cell responses in the context of multiple HCV exposures is critical to identify broadly protective immune responses necessary for an effective HCV vaccine against the different HCV genotypes. However, host and viral genetic diversity complicates vaccine development. To compensate for the observed variation in circulating autologous viruses and host...

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Share to CD8-Positive T-Lymphocytes
Share to Enzyme-Linked Immunospot Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26107956
DOI: 10.1371/journal.pone.0130420
PMCID: PMC4480353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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