Evidence of CD4+ T cell-mediated immune pressure on the Hepatitis C virus genome.

doi:10.1038/s41598-018-25559-6

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Article

Evidence of CD4+ T cell-mediated immune pressure on the Hepatitis C virus genome.

Scientific reports - 8 May 2018

Lucas Michaela, Deshpande Pooja, James Ian, Rauch Andri, Pfafferott Katja, Gaylard Elouise, Merani Shahzma, Plauzolles Anne, Lucas Andrew, McDonnell Wyatt, Kalams Spyros, Pilkinton Mark, Chastain Cody, Barnett Louise, Prosser Amy, Mallal Simon, Fitzmaurice Karen, Drummer Heidi, Ansari M Azim, Pedergnana Vincent, Barnes Ellie, John Mina, Kelleher Dermot, Klenerman Paul, Gaudieri Silvana

Abstract excerpt

Hepatitis C virus (HCV)-specific T cell responses are critical for immune control of infection. Viral adaptation to these responses, via mutations within regions of the virus targeted by CD8+ T cells, is associated with viral persistence. However, identifying viral adaptation to HCV-specific CD4+ T cell responses has been difficult although key to understanding anti-HCV immunity. In this context, HCV sequence and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29740042
DOI: 10.1038/s41598-018-25559-6
PMCID: PMC5940905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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