Article
Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations.
Hepatology (Baltimore, Md.) - 1 Oct 2011
Neumann-Haefelin Christoph, Oniangue-Ndza Cesar, Kuntzen Thomas, Schmidt Julia, Nitschke Katja, Sidney John, Caillet-Saguy Célia, Binder Marco, Kersting Nadine, Kemper Michael W, Power Karen A, Ingber Susan, Reyor Laura L, Hills-Evans Kelsey, Kim Arthur Y, Lauer Georg M, Lohmann Volker, Sette Alessandro, Henn Matthew R, Bressanelli Stéphane, Thimme Robert, Allen Todd M
Abstract excerpt
UNLABELLED: Human leukocyte antigen B27 is associated with spontaneous viral clearance in hepatitis C virus (HCV) infection. Viral escape within the immunodominant, HLA-B27-restricted, HCV-specific, cluster of differentiation (CD)8(+) T-cell epitope, nonstructural protein (NS)5B(2841-2849) (ARMILMTHF), has been shown to be limited by viral fitness costs as well as broad T-cell cross-recognition, suggesting a...
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