Article
Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution.
Hepatology (Baltimore, Md.) - 1 Mar 2006
Neumann-Haefelin Christoph, McKiernan Susan, Ward Scott, Viazov Sergei, Spangenberg Hans Christian, Killinger Thomas, Baumert Thomas F, Nazarova Natalja, Sheridan Isabelle, Pybus Oliver, von Weizsäcker Fritz, Roggendorf Michael, Kelleher Dermot, Klenerman Paul, Blum Hubert E, Thimme Robert
Abstract excerpt
Virus-specific CD8+ T cell responses play an important role in the natural course of infection; however, the impact of certain CD8+ T cell responses in determining clinical outcome has not been fully defined. A well-defined cohort of women inoculated with HCV from a single source showed that HLA-B27 has a strong association with spontaneous clearance. The immunological basis for this association is unknown....
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