Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Susceptibility to chronic hepatitis C virus infection is influenced by sequence differences in immunodominant CD8+ T cell epitopes.

Journal of hepatology - 1 Jan 2013

Ziegler Susanne, Ruhl Marianne, Tenckhoff Hannelore, Wiese Manfred, Heinemann Falko M, Horn Peter A, Spengler Ulrich, Neumann-Haefelin Christoph, Nattermann Jacob, Timm Jörg

Abstract excerpt

BACKGROUND & AIMS: The antiviral immune response against HCV by CD8+ T cells plays a central role in viral containment. In a large HCV genotype 1b outbreak in Ireland, HLA-B(∗)08 was identified as a risk allele for chronic infection and HLA-A(∗)03 and HLA-B(∗)27 were associated with higher clearance rates. Here we took advantage of a similar large common source HCV genotype 1b outbreak (East-German cohort) to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-A3 Antigen

Share to HLA-B Antigens

Share to HLA-B27 Antigen

Share to HLA-B8 Antigen

Share to Immunodominant Epitopes

Share to Ireland

Source

Identifiers

PMID: 22925811
DOI: 10.1016/j.jhep.2012.08.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Susceptibility to chronic hepatitis C virus infection is influenced by sequence differences in immunodominant CD8+ T cell epitopes.PMID 22925811Read ↗

Human leukocyte antigen–associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution†Semantic proximity Read ↗

Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection.Semantic proximity Read ↗

Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes.Semantic proximity Read ↗

Immune escape pathways from the HBV core18-27 CD8 T cell response are driven by individual HLA class I alleles.Semantic proximity Read ↗

Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution.Semantic proximity Read ↗

Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations.Semantic proximity Read ↗

Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source.Semantic proximity Read ↗

Distinct Escape Pathway by Hepatitis C Virus Genotype 1a from a Dominant CD8+ T Cell Response by Selection of Altered Epitope Processing.Semantic proximity Read ↗

Escape from HLA-B*08-restricted CD8 T cells by hepatitis C virus is associated with fitness costs.Semantic proximity Read ↗

IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study.Semantic proximity Read ↗

Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection.Semantic proximity Read ↗

The interaction of genetic determinants in the outcome of HCV infection: evidence for discrete immunological pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.