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Article

Positive selection of cytotoxic T lymphocyte escape variants during acute hepatitis C virus infection

22 Aug 2005

Abstract excerpt

Cellular immune responses are induced during hepatitis C virus (HCV) infection and acute-phase CD8+ T cells are supposed to play an important role in controlling viral replication. In chimpanzees, failure of CD8+ T cells to control HCV replication has been associated with acquisition of mutations in MHC class I-restricted epitopes. In humans, although selection of escape mutations in an immunodominant CTL epitope...

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PMID: 16114108
DOI: 10.1002/eji.200526067

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