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Article

Innate IL-23/Type 17 immune responses mediate the effect of the 17q21 locus on childhood asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jul 2021

Wang Ni, Brix Susanne, Larsen Jeppe M, Thysen Anna H, Rasmussen Morten A, Workman Christopher T, Stokholm Jakob, Bønnelykke Klaus, Bisgaard Hans, Chawes Bo L

Abstract excerpt

BACKGROUND: Several childhood asthma risk loci that relate to immune function have been identified by genome-wide association studies (GWAS), but the underlying mechanisms remain unknown. OBJECTIVE: Here, we examined whether perturbed innate immune responses mediate the association between known genetic risk variants and development of childhood asthma. METHODS: Peripheral blood mononuclear cells from...

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Identifiers

PMID: 33987892
DOI: 10.1111/cea.13900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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